The broad area of exercise in the management and prevention of disease has been the focus of my research. The ultimate aim of this work is translational focused on improving scientific exercise prescription to optimise therapeutic responses to exercise interventions in chronic disease and particularly cancer. While there is strong evidence at an epidemiological level for the benefit of exercise in the prevention and treatment of disease, much remains to be discovered regarding dose response. With an increase in the incidence of obesity and chronic disease there is a need for research into optimising therapeutic responses through exercise. The validation of methods to measure physical activity has been an area of ongoing investigation and has informed a number of the methodologies currently being performed.
The current activities in this research programme in exercise rehabilitation in cancer management include: the examination of insulin resistance, lipids and inflammatory markers and the relationship with fitness and activity in breast cancer survivors, modifiable risk factors in unaffected BRCA 1 and BRCA 2 gene carriers, the effects of an eight week exercise intervention on physical performance measures in patients after chemotherapy, and the effect of exercise interventions preoperatively for those with oesophageal cancer.