ToPCaP

Ireland Prostate Cancer Research Consortium Cohort

Ireland Prostate Cancer Research Consortium Cohort

The Prostate Cancer Research Cohort (PCRC) has established a federated prostate cancer bio-resource at its hospital sites Mater Miseracordiae University Hospital (MMUH), St. James's Hospital (SJH), and Beaumont Hospital (BH) following ethical approval by each of the hospitals ethics committees and the Irish data protection commissioner. Using the federated collection model, agreed standard operating procedures have been established and implemented across the different sites by dedicated research nurses for, informed consent, sample collection and initial processing which provides uniformity in resources. These procedures are essential as the eventual validity and usefulness of the biomarker discovery depends heavily on the composition and quality of the clinical specimens used in the generation of data. Central to the federated collection is the Bioresource Information and Management System (BIMS) architecture which accommodates the collection and tracking of samples and integration of clinical information. Data entry is also carried out by the research nurses who also manage the patient identifiable information and update the database with follow up information including PSA, other treatments and mortality. The focus of the resource was to collect a radical prostatectomy cohort of patients to discover and validate biomarker for grade and stage of disease and this has been expanded to indolent and aggressive disease as well. The cohort is comprised of 622 cases of radical prostatectomy and 50 TURPs for benign disease collected for 2004 and 2011 and is an on-going collection.